The ITGB2 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to Integrin beta 2, and ITGB2. This antibody recognizes Human antigen. The ITGB2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
The product of this gene belongs to the integrin beta
chain family of proteins. Integrins are integral cell-surface
proteins composed of an alpha chain and a beta chain. This gene
encodes the integrin beta chain beta 2. A given chain may combine
with multiple partners resulting in different integrins. For
example, beta 2 combines with the alpha L chain to form the
integrin LFA-1, and combines with the alpha M chain to form the
integrin Mac-1. Integrins are known to participate in cell adhesion
as well as cell-surface mediated signalling. Defects in this gene
are the cause of leukocyte adhesion deficiency type I (LAD1). Two
transcript variants encoding the same protein have been identified
for this gene